Vitamin D and Vitamin D Receptor Polymorphisms Relationship to Risk Level of Dental Caries

Dental caries is a multifactorial disease with multiple risk factors. Vitamin D levels (VDLs) and vitamin receptor polymorphisms (VDRPs) have been investigated for this reason. The aim of narrative review to investigate the relation factors affecting deficiency (VDD), VDRP, Early Childhood Caries (ECC) Severe (S-ECC) in children (primary mixed dentition) dental adults (permanent dentition). Additionally, we present model incorporating interactions that address relationship. Methods: Three databases (PubMed/MEDLINE, Web Science, Cochrane Library) were comprehensively searched until 17 January 2023 using following keywords: “vitamin D”, polymorphism”, “dental caries”, risk”, finding 341 articles. Two reviewers searched, screened, extracted information from selected All pooled analyses based on random-effects models. Eligibility criteria articles dmft/DMFT diagnostic calibrated examiners, probability sampling, sample sizes. We excluded studies conducted institutionalized patients. A total 32 finally used. Results: In most studies, TaqI, FokI, BsmI affected prevalence caries. strong correlation between ECC, S-ECC, was reported association VDD maternal intake VD primary dentition. Regarding influence dentition, results found be inconclusive. slight positive permanent Conclusions: Factors intake, socioeconomic factors, level VD. There certain need more well-conducted will VDR gene specifically adult